Si Chen, PhD.
Scientific background:
Additive manufacturing (DLP, SLA, FDM), bioactive glasses, composite materials, porous materials, surface modification, surface functionalization, polyphenol chemistry, hydrogels, sol-gel method, blood-contacting coating, nanoparticles, microspheres, flame synthesis, conventional melt quenching, electrospinning, vascular endothelialisation, bone regeneration, anticoagulation, angiogenesis, biomineralisation, drug-eluting coatings, antimicrobial, anti-inflammatory, immunomodulation
International projects:
- Cultivating Leaders for Innovative Coatings and Additive Manufacturing (CLiCAM), HORIZON-WIDERA-2022-TALENTS-03, Participant
National projets:
- APVV-22-0036, 3D bioactive glass scaffold mimicking natural bone with therapeutic effects for bone tissue applications, 2023-2027, Principal Investigator
- APVV-22-0036 booster grant, 2024, Principal Investigator
- VEGA 1/0057/23, Hierarchical porous scaffolds and hydrogel composites from bioactive glass nanoparticle/microsphere with multi-therapeutic effect for regenerative medicine, 2023-2026, Principal Investigator
- VEGA 1/0098/19, Multi-layered bioglass structures for regenerative medicine prepared by tape casting and lamination, 2019-2022, deputy of the project leader
- SK-CN-21-0022, Multifunctional bioactive coatings for Ti- and Zr- based dental implants, 2022-2023, main participant (application writing, communication with collaborator)
- APVV-20-0322, Nanostructured, functionally graded, and bioinspired 3D Ti-based implants, 2021-2025, participant
Publication activity:
- Chapters in monographs: 3
- Publications in scientific journals: 21
- Citations: 665
The most significant publications:
2026
- Martin Michálek, Si Chen. Chapter 6: Biomaterials. FunGlass Handbook of Glass and Ceramics Science Volume 1. Materials. FunGlass – Centre for Functional and Surface Functionalized Glass, Alexander Dubček Trenčín University. (Book)
- Zulema Vargas Osorio, Si Chen. Chapter 3: Surface modification of nanoparticles. FunGlass Handbook of Glass and Ceramics Science Volume 2. Synthesis and Processing Methods. FunGlass – Centre for Functional and Surface Functionalized Glass, Alexander Dubček Trenčín University. (Book)
- Jozef Kraxner, Mokthar Mahmoud, Arish Dasan, Si Chen. Chapter 2: Glass Microspheres. FunGlass Handbook of Glass and Ceramics Science Volume 1. Materials. FunGlass – Centre for Functional and Surface Functionalized Glass, Alexander Dubček Trenčín University. (Book)
- Ertugrul Varlik, Lenka Drotárová, Abel W. Ourgessa, Martina Vitázková, Qaisar Nawaz, Si Chen, Edgar B. Montufar, Dušan Galusek, Aldo R. Boccaccini, and Martin Michálek. “Low‐temperature sintered boron‐doped S53P4 bioactive glass scaffolds fabricated by robocasting.” Journal of the American Ceramic Society 109, no. 1 (2026): e70292.
2025
- Ertugrul Varlik, Lucille Viviant, Fatih Kurtuldu, Qaisar Nawaz, Si Chen, Jozef Kraxner, Dušan Galusek, Martin Michálek, and Aldo R. Boccaccini. “Bioactive glass (BG) particle shape affects the mechanical and biological properties of PLA/BG scaffolds for bone regeneration.” Materials Letters (2025): 139383.
- Si Chen, A. A. Altun, S. Nohut, M. Schwentenwein, B. Baďurová, H. Škovierová, M. Schwentenwein, D. Galusek, M. Michálek. Advanced 3D-Printed Borate Bioactive Glass Scaffolds for Bone Repair Using Vat Photopolymerization. 34th Annual Conference of the European Society for Biomaterials, 7-11 September, 2025, Torino, Italy, Oral, B6-54.
2024
- Si Chen, Meng Li, Martin Michálek, Hana Kaňková, Liang Zhao, Aldo R. Boccaccini, Dušan Galusek, Kai Zheng. Cross-linking of mesoporous bioactive glass nanoparticle reinforced gelatin hydrogels by tannic acid with enhanced mechanical performance and stability. Materialia, 2024: 102165.
- Eskandarinia A, Morowvat MH, Niknezhad SV, Baghbadorani MA, Michálek M, Chen S, Nemati MM, Negahdaripour M, Heidari R, Azadi A, Ghasemi Y. A photocrosslinkable and hemostatic bilayer wound dressing based on gelatin methacrylate hydrogel and polyvinyl alcohol foam for skin regeneration. International Journal of Biological Macromolecules, 2024, Mar 28:131231.
- Si Chen, Martin Michálek, Eduin Ivan González Castillo, Branislav Hruška, Ali Talimian, Juraj Šurka, Hana Kaňková et al. The effect of alkali activation on the textural properties of flame-synthesized 45S5-derived micron-porous bioactive glass microspheres. Materialia, 2024: 102023.
- Si Chen, A. A. Altun, S. Nohut, M. Michálek, M. Schwentenwein, D. Galusek. 3D Printing of Multi-Material Bioactive Glasses via Digital Light Processing. 8th China-Europe symposium on biomaterials in regenerative medicine, 15-18 September, 2024, Nuremberg, Germany, Oral, OS12-8.
2023
- Huili Lei, Xuan Zhang, Si Chen, Chengbo Li, and Guojiang Wan. Liquid Phase Deposition of TiO2 on a Multifunctional Template of Grafted Gallic Acid and Hexamethylenediamine (GAHD) with Enhanced Electrochemical Properties. Coatings, 2023, 13(9): 1600.
- Si Chen, Jozef Kraxner, Martin Michálek, Dušan Galusek. Textural properties and the mechanism of pore formation in 45S5 bioactive glass microspheres fabricated by alkali activation-flame synthesis. 33rd Annual Conference of the European Society for Biomaterials, 4-8 September, 2023, Davos, Switzerland, Poster, PoA.12.01.
2022:
- Vargas-Osorio, Z., Ruther, F., Chen, S., Sengupta, S., Liverani, L., Michálek, M., Galusek, D., Boccaccini, A. R. Environmentally friendly fabrication of electrospun nanofibers made of polycaprolactone, chitosan and κ-carrageenan (PCL/CS/κ-C). Biomedical Materials, 2022, 17(4), 045019.
- Mahmoud, M., Kraxner, J., Kaňková, H., Hujová, M., Chen, S., Galusek, D., Bernardo, E. Porous Glass Microspheres from Alkali-Activated Fiber Glass Waste. Materials, 2022, 15(3), 1043.
2021:
- Wekwejt, M., Chen, S., Kaczmarek-Szczepańska, B., Nadolska, M., Łukowicz, K., Pałubicka, A., Michno A., Osyczka A. M., Michálek M., Zieliński, A. Nanosilver-loaded PMMA bone cement doped with different bioactive glasses–evaluation of cytocompatibility, antibacterial activity, and mechanical properties. Biomaterials science, 2021, 9(8), 3112-3126.
- Kurtuldu, F., Mutlu, N., Michálek, M., Zheng, K., Masar, M., Liverani, L., Chen S., Galusek D., Boccaccini, A. R. Cerium and gallium containing mesoporous bioactive glass nanoparticles for bone regeneration: Bioactivity, biocompatibility and antibacterial activity. Materials Science and Engineering: C, 2021, 124, 112050.
- Si Chen, Jozef Kraxner, Martin Michálek, Dušan Galusek. The effect of alkali activation on the porosity of 45S5 bioactive glass microspheres. 31st Conference of the European Society for Biomaterials (ESB) together with the 43rd Annual Congress of the Iberian Society of Biomechanics and Biomaterials (SIBB), 5-9 September, 2021, Fully virtual, Porto, Portugal, Oral, N09-09.
2020:
- Si Chen, Dagmar Galusková, Hana Kaňková, Kai Zheng, Martin Michálek, Liliana Liverani, Dušan Galusek, Aldo R. Boccaccini. Electrospun PCL Fiber Mats Incorporating Multi-Targeted B and Co Co-Doped Bioactive Glass Nanoparticles for Angiogenesis. Materials. 2020, 13(18): 4010.
- Si Chen, Martin Michálek, Dagmar Galusková, Monika Michálková, Peter Švančárek, Ali Talimian, Hana Kaňková, Jozef Kraxner, Kai Zheng, Liliana Liverani, Dušan Galusek, Aldo R. Boccaccini. Multi-targeted B and Co co-doped 45S5 bioactive glass with angiogenic potential for bone regeneration. Materials Science and Engineering: C. 2020: 110909.
2019:
- Si Chen, Sheng Zhao, Meiyun Chen, Xuan Zhang, Jiang Zhang, Xin Li, Hao Zhang, Xiaolong Shen, Jin Wang, Nan Huang. The anticorrosion mechanism of phenolic conversion coating applied on magnesium implants. Applied Surface Science, 2019, 463: 953-967.
- Si Chen, Martin Michálek, Dagmar Galusková, Monika Michálková, Peter Švančárek, Ali Talimian, Hana Kaňková, Jozef Kraxner, Liliana Liverani, Dušan Galusek, Aldo R. Boccaccini. Development and characterization of B and Co ions co-doped 45S5 bioactive glass for possible use in angiogenesis. 30th annual conference of the European society for biomaterials together with the 26th annual conference of the German society for biomaterials, 9-13 September, 2019, Dresden, Germany, Oral, I-SY1-03
2018:
- Xin Li, Fangyu Shen, Kebing Wang, Shuang Lin, Lei Zhou, Si Chen, Jin Wang, Nan Huang. Endothelial mimetic multifunctional surfaces fabricated: Via polydopamine mediated copper immobilization. Journal of Materials Chemistry B, 2018, 6(46): 7582-7593.
2016:
- Xin Li, Jinchuan Deng, Shuheng Yuan, Rifang Luo, Si Chen, Jin Wang, Nan Huang. Fabrication of endothelial progenitor cell capture surface via DNA aptamer modifying dopamine/polyethyleneimine copolymer film. Applied Surface Science. 2016, 386: 138-150.
2015:
- Si Chen, Jiang Zhang, Yingqi Chen, Sheng Zhao, Meiyun Chen, Xin Li, Manfred F Maitz, Jin Wang, Nan Huang. Application Of Phenol/Amine Copolymerized Film Modified Magnesium Alloys: Anticorrosion And Surface Bio-functionalization. ACS Applied Materials & Interfaces. 2015, 7(44): 24510-24522.
- Xin Li, Shuheng Yuan, Si Chen, Rifang Luo, Kaiqin Xiong, Jin Wang, Zhi Lu Yang, Nan Huang. Proliferation and Functionality of Human Umbilical Vein Endothelial Cells on Angiopoietin-1 Immobilized 316L Stainless Steel. Journal of Materials Chemistry B. 2015, 3(44): 8717-8728.
- Jiang Zhang, Yang Liu, Rifang Luo, Si Chen, Xin Li, Shuheng Yuan, Jin Wang, Nan Huang. In vitro hemocompatibility and cytocompatibility of dexamethasone-eluting PLGA stent coatings. Applied Surface Science. 2015, 328: 154-162.
2014:
- Si Chen, Xin Li, Zhilu Yang, Shuo Zhou, Rifang Luo, Manfred F. Maitz, Yuancong Zhao, Jin Wang, Kaiqin Xiong, Nan Huang. A simple one-step modification of various materials for introducing effective multi-functional groups. Colloids and Surfaces B: Biointerfaces. 2014, 113: 125-133.
- Pengkai Qi, Si Chen, Tao Liu, Jialong Chen, Zhilu Yang, Yajun Weng, Junying Chen, Jin Wang, Manfred F. Maitz, Nan Huang. New strategies for developing cardiovascular stent surfaces with novel functions. Biointerphases. 2014, 9(2): 029017.
- Si Chen, Jiang Zhang, YingQi Chen, Jin Wang, Nan Huang. Simple one-step deposition of polyphenolic copolymer films on the surface of magnesium alloys for anticorrosion and functionalization. 4th International Colloids Conference, Surface Design and Engineering, 15-18 June, 2014, Madrid, Spain, Poster, P1.64.
2013:
- Si Chen, Zhilu Yang, Jin Wang. Co-polymerization of hexamethylenediamine (HD) and Gallic acid (GA) to prepare multifunctional coatings. The 4th Asian Biomaterials Congress, 26-29 June, 2013, Hong Kong, China, Oral, CD4.
2011:
- Zhilu Yang, Jin Wang, Rifang Luo, Xin Li, Si Chen, Hong Sun, Nan Huang. Improved hemocompatibility guided by pulsed plasma tailoring the surface amino functionalities of TiO2 coating for covalent immobilization of heparin. Plasma Processes and Polymers. 2011, 8(9): 850-858.
Doctoral studies:
Study part: Profile subjects:
Inorganic technologies and materials II
Modules:
Sol-gel and Surface modification of nanoparticles
Scientific part:
Supervisor of PhD. students
Experimental work I-IX, Publication activity I and II, Active participation in a conference I and II
Education:
- 2009-09.2015 Ph.D, Material Science, Key Lab. of Advanced Technology for Materials of Education Ministry, Southwest Jiaotong University, China. Title of the thesis: Polydopamine-like coating — preparation and performance of gallic acid/hexamethelinediamine copolymerized film.
- 2007-07.2009 M.S. , Biomedical Engineering, Key Lab. of Advanced Technology for Materials of Education Ministry, Southwest Jiaotong University, China. Successive postgraduate and doctoral programs of study.
- 2003-07.2007 B.S., Pharmaceutical Engineering, School of pharmacy, Southwest Jiaotong University, China. Title of the thesis: Preliminary Study on Extraction Technology and Antioxidant Activity in vitro of Gastrodia elata Polysaccharide.
Awards, scholarships and research stays:
- 2025-09.2025 Visiting scientist (additive manufacturing), Lithoz GmbH – Vienna, Austria
- 2024-05.2024 Visiting scientist (additive manufacturing), Lithoz GmbH – Vienna, Austria
- 2018-08.2019 Visiting scientist (mesoporous bioactive glass nanoparticles, electrospinning, bone regeneration), Institute of Biomaterials, University of Erlangen – Nuremberg, Germany
- NUST „MISiS“ International Competition for Grants (The open international grant competition of National University of Science and Technology «MISiS» designed to support Young scientists), 2017, Winner.
Other activities:
- Membership of Slovak Silicate Society
- Membership of European Ceramic Society
- Membership of Topical Advisory Panel, Materials (MDPI)
- Review Editor: Biomaterials Section, Frontiers in Bioengineering and Biotechnology (Frontiers)
- Editor: Special Issue on “Advanced Biomaterials and Technologies for Oral and Maxillofacial Regeneration”, Frontiers in Bioengineering and Biotechnology (Frontiers)








